Mpox Outbreak 2025 Countries List. The monkeypox virus is an orthopoxvirus that causes mpox (monkeypox), a disease with symptoms similar to smallpox, although less severe. At least 12 african countries, including previously unaffected nations like burundi, kenya, rwanda, and uganda, have reported mpox outbreaks.

The three countries with the majority of the cases in 2025 are. Since the beginning of mpox monitoring in 2022, and as of 31 july 2025, over 100 000 confirmed cases of mpox due to monkeypox virus (mpxv) clade i and clade ii,.